ITSP's SmartSPE™ is online SPE that delivers easy to operate high throughput automation in a single robust sample cleanup / measurement workflow. Only ITSP achieves LC column performance in a single use SPE device!
ISOLUTE® HCX combines non-polar (C8) and strong cation exchange retention (SO3-) mechanisms to isolate basic analytes from complex aqueous matrices such as urine and plasma. Analytes are initially retained by a non-polar retention mechanism, with inorganic salts, polar interferences such as phospholipids and large molecular weight peptides and proteins passing directly through the sorbent bed. The pH is then adjusted to allow an ion exchange retention mechanism to retain the analyte(s). Non-polar interferences are removed using an organic solvent or organic solvent/water wash. Analytes are then eluted in an extra clean fraction.